AI Article Synopsis
- The use of traditional drugs for cardiac injury is limited by their low specificity for the heart, leading to ineffective treatment.
- Nanostructured lipid carriers (NLCs) have been developed to deliver medications more effectively, but they tend to target the liver more than the heart.
- A new cardiac extracellular matrix (ECM) hydrogel-NLC composite has been created, which delivers drugs like colchicine directly to the heart, improving recovery after heart attacks in mice while enhancing overall treatment effectiveness.
Article Abstract
A challenge in treating cardiac injury is the low heart-specificity of the drugs. Nanostructured lipid carriers (NLCs) are a relatively new format of lipid nanoparticles which have been used to deliver RNA and drugs. However, lipid nanoparticles exhibit higher affinity to the liver than the heart. To improve the delivery efficiency of NLCs into the heart, NLCs can be embedded into a scaffold and be locally released. In this study, a cardiac extracellular matrix (ECM) hydrogel-NLC composite was developed as a platform for cardiac repair. ECM-NLC composite gels at physiological conditions and releases payloads into the heart over weeks. ECM-NLC hydrogel carrying colchicine, an anti-inflammation agent, improved cardiac repair after myocardial infarction in mice. Transcriptome analysis indicated that Egfr downstream effectors participated in ECM-NLC-colchicine induced heart repair. In conclusion, ECM-NLC hydrogel is a potential platform for sustained and localized delivery of biomolecules into the heart, and loading appropriate medicines further increases the therapeutic efficacy of ECM-NLC hydrogel for cardiovascular diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.biomaterials.2023.122364 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model.
Arch Toxicol
January 2025
Department of Medicine, University of California, San Diego, CA, 92093, USA.
E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.
View Article and Find Full Text PDFRobotic mitral valve surgery: evolving history, techniques, and training paths.
Curr Opin Cardiol
January 2025
Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Purpose Of Review: Over the past 25 years, robotic-assisted mitral valve surgery has gained significant recognition because of its potential to minimize patient trauma and improve clinical outcomes. This field has evolved from early efforts in minimally invasive mitral procedures to more refined and technically sophisticated approaches, driven by the need for smaller incisions and reduced recovery times.
Recent Findings: This review will delve into the historical evolution of robotic-assisted mitral valve surgery, detailing the technical advancements that have shaped current practices and outlining the essential training pathways for a career as robotic mitral valve surgeon.
Safety and efficacy of the automated suture system in valvular heart surgery: a multicenter, prospective registry.
J Cardiovasc Surg (Torino)
December 2024
Department of Cardiovascular and Thoracic Surgery, Dijon University Hospital, Dijon, France.
Background: In the last years, the Cor-Knot device has been increasingly used in heart valve surgery. Our aim was to investigate the incidence of valvular complications in patients who underwent valvular surgery using the Cor-Knot device in multicentric cohorts at one-year follow-up.
Methods: Three hundred and sixty-eight patient underwent heart valve repair or replacement surgery using automated titanium suture fasteners in four cardiothoracic surgery departments between September 2018 and January 2020.
The hemi-Mustard-bidirectional Glenn-Rastelli procedure for repair of congenitally corrected transposition of the great arteries, pulmonary atresia and dextrocardia.
Kardiochir Torakochirurgia Pol
December 2024
Department of Pediatric Cardiac Surgery, Jagiellonian University Medical College, Krakow, Poland.
Redo Minimally Invasive Right Atrial Mass Removal After Surgical Atrial Septal Defect Closure.
J Saudi Heart Assoc
December 2024
Department of Radiology, U.N Mehta Institute of Cardiology and Research Centre, Ahmedabad, Gujarat, India.
Atrial septal defects are among the most prevalent congenital anomalies necessitating surgical intervention. Thrombus formation is a recognized complication that is typically characterized by an embolic event following patch-based repair. However, thromboembolic complications following primary repair of atrial septal defects are exceedingly uncommon.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!