Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.adk7900 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Asiatic acid methyl ester, a new asiaticoside derivative, induces osteogenic differentiation of hPDLCs.
Arch Oral Biol
January 2025
Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellent in Natural Products and Nanoparticles (NP2), Chulalongkorn University, Bangkok, Thailand.
Objective: Asiaticoside has the capacity to induce osteogenic differentiation of human periodontal ligament cells (hPDLCs) through Wnt (Wingless-related integration site) signaling. A modified chemical structure (by removing glycoside side chain), referred to as asiatic acid methyl ester (AA1), has been constructed and evaluated for its capacity to induce osteogenic differentiation.
Design: hPDLCs viability was determined by MTT assay.
Genetic structure of populations in wildlife of north and northeast Iran.
Int J Parasitol Parasites Wildl
April 2025
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
is a parasite prevalent in the temperate regions of the vast Palearctic realm, including Iran. In this study, we investigated infection in road-killed animals and carcasses in northern and northeastern Iran by artificial digestion. We assessed species identification and intraspecific genetic diversity using the markers 5S ribosomal DNA intergenic spacer (5S rDNA), internal transcribed spacer I (ITS1), and cytochrome oxidase subunit I ().
View Article and Find Full Text PDFQuantifying sustainable urbanization by predictive modeling for better agricultural management: A case study in the South Asiatic Region.
Heliyon
January 2025
Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology, Yunnan University, Kunming, 650500, China.
Global population growth and uncontrolled are creating threats to agricultural land. To address urbanization, proactive planning is required. Land use and land cover (LULC) classification maps for 2002-2022 were analyzed using remote sensing (RS) and geographic information systems (GIS) in Sahiwal, Punjab, Pakistan.
View Article and Find Full Text PDFGenomic evidence of improved fertility and adaptation in Iranian domestic sheep attributed to introgression from Asiatic Mouflon and urial.
Sci Rep
January 2025
School of Agriculture, Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC, 3010, Australia.
Due to the diverse climate in Iran, there has been an opportunity for the emergence of different domestic sheep breeds. On the other hand, two of the seven wild sheep species have settled in the broad areas of Iran. This study investigated the introgression between wild and domestic Iranian sheep using the whole genome sequencing data for 55 domestic and 19 wild sheep.
View Article and Find Full Text PDF[Reversal Roles and Its Mechanism of Asiatic Acid on Multidrug Resistance in K562/ADR Cells Through the Wnt/β-catenin Pathway].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Pediatrics， Binzhou Medical University Hospital， Binzhou 256603, Shandong Province， China.
Article Synopsis
- The study aimed to explore how asiatic acid (AA) affects the drug resistance in human leukemia cells (K562/ADR) resistant to adriamycin (ADR).
- AA was found to reduce the resistance of these cells and enhance the effectiveness of ADR, as shown by various assays including CCK-8 and flow cytometry.
- The results indicated that AA down-regulates the expression of certain proteins related to drug resistance, suggesting a potential mechanism for reversing resistance in these cancer cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!