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Paradoxical Inflammatory Bowel Disease Induced by Golimumab in a Patient With Ankylosing Spondylitis: A Case Report and Systematic Review.
Cureus
January 2025
Faculty of Medicine, University of Hama, Hama, SYR.
Paradoxical reactions (PRs) to biologic medications, such as psoriasis, arthritis, and inflammatory bowel disease (IBD), have been increasingly recognized. The aim of reporting this case is to establish an association between golimumab and exacerbation or new (de novo) IBD in patients with axial spondyloarthritis (SpA). Our case involves a young patient with juvenile-onset ankylosing spondylitis (AS) who developed de novo IBD following golimumab therapy for active spinal disease.
View Article and Find Full Text PDFRevisions of the Phenomenological and Statistical Statements of the Second Law of Thermodynamics.
Entropy (Basel)
December 2024
Istituto Nazionale di Alta Matematica (INdAM), 00185 Rome, Italy.
The status of the Second Law of Thermodynamics, even in the 21st century, is not as certain as when Arthur Eddington wrote about it a hundred years ago. It is not only about the truth of this law, but rather about its strict and exhaustive formulation. In the previous article, it was shown that two of the three most famous thermodynamic formulations of the Second Law of Thermodynamics are non-exhaustive.
View Article and Find Full Text PDFThe Quantum Memory Matrix: A Unified Framework for the Black Hole Information Paradox.
Entropy (Basel)
November 2024
Terra Quantum AG, Kornhausstrasse 25, 9000 St. Gallen, Switzerland.
We present the Quantum Memory Matrix (QMM) hypothesis, which addresses the longstanding Black Hole Information Paradox rooted in the apparent conflict between Quantum Mechanics (QM) and General Relativity (GR). This paradox raises the question of how information is preserved during black hole formation and evaporation, given that Hawking radiation appears to result in information loss, challenging unitarity in quantum mechanics. The QMM hypothesis proposes that space-time itself acts as a dynamic quantum information reservoir, with quantum imprints encoding information about quantum states and interactions directly into the fabric of space-time at the Planck scale.
View Article and Find Full Text PDFReconciling Archean organic-rich mudrocks with low primary productivity before the Great Oxygenation Event.
Proc Natl Acad Sci U S A
January 2025
Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125.
The organic carbon content of ancient rocks provides a fundamental record of the biosphere on early Earth. For over 50 y, the high organic content of Archean (>2.5 Ga) mudrocks has puzzled geologists and evolutionary biologists, because high biological primary productivity was unexpected for the nascent biosphere before the rise of O.
View Article and Find Full Text PDFA unified neurocomputational model of prospective and retrospective timing.
Psychol Rev
January 2025
Department of Experimental Psychology, University of Groningen.
Time is a central dimension against which perception, action, and cognition play out. From anticipating when future events will happen to recalling how long ago previous events occurred, humans and animals are exquisitely sensitive to temporal structure. Empirical evidence seems to suggest that estimating time prospectively (i.
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