AI Article Synopsis
- Cancer stem cells (CSCs) are special cells in tumors that can self-renew and differentiate, playing a crucial role in tumor recurrence and spread, making them key targets for cancer treatments.
- Recent research shows that CSCs have unique metabolic characteristics that differ from regular tumor cells, which help maintain their stem-like properties and influence their transformation.
- Understanding these metabolic changes and the mechanisms behind them could lead to new strategies for developing cancer therapies.
Article Abstract
Cancer stem cells (CSCs) are a class of cells with self-renewal and multi-directional differentiation potential, which are present in most tumors, particularly in aggressive tumors, and perform a pivotal role in recurrence and metastasis and are expected to be one of the important targets for tumor therapy. Studies of tumor metabolism in recent years have found that the metabolic characteristics of CSCs are distinct from those of differentiated tumor cells, which are unique to CSCs and contribute to the maintenance of the stemness characteristics of CSCs. Moreover, these altered metabolic profiles can drive the transformation between CSCs and non-CSCs, implying that these metabolic alterations are important markers for CSCs to play their biological roles. The identification of metabolic changes in CSCs and their metabolic plasticity mechanisms may provide some new opportunities for tumor therapy. In this paper, we review the metabolism-related mechanisms of CSCs in order to provide a theoretical basis for their potential application in tumor therapy.
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| http://dx.doi.org/10.1007/s11010-023-04861-6 | DOI Listing |
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