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The Current Mismatch Between COVID-19 Clinical Trial Design and the Evolving Profile of Hospitalized Patients: A Retrospective Cohort Analysis. | LitMetric

The Current Mismatch Between COVID-19 Clinical Trial Design and the Evolving Profile of Hospitalized Patients: A Retrospective Cohort Analysis.

Clin Infect Dis

Infectious Diseases Unit, Internal Medicine Department, La Paz University Hospital, Instituto de Investigación del Hospital Universitario La Paz, School of Medicine, Autonomous University of Madrid, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Madrid, Spain.

Published: April 2024

AI Article Synopsis

  • Researchers evaluated 100 adult COVID-19 patients at a hospital in Madrid and found that many did not qualify for clinical trials due to strict design criteria.
  • This mismatch indicates that current trial designs may not accurately reflect the characteristics of hospitalized COVID-19 patients.
  • The study suggests reevaluating trial criteria to ensure a better representation of this patient group in future research.

Article Abstract

Evaluating 100 adult coronavirus disease 2019 (COVID-19) patients at a Madrid hospital, we identified a mismatch between current clinical trial designs and the evolving profile of hospitalized patients. Most patients were ineligible due to design constraints, suggesting a need to rethink trial criteria for a more accurate representation of the hospitalized COVID-19 cohort.

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Source
http://dx.doi.org/10.1093/cid/ciad655DOI Listing

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