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Diversity and Prevalence of Helminths and Protozoa Among Pregnant Women in Tropical Ecuador: Implications for Chemotherapy.
Am J Trop Med Hyg
November 2024
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Deworming for pregnant women using a single dose of albendazole or mebendazole is recommended by the WHO in areas where the baseline prevalence of hookworm and/or trichuriasis is >20%. However, other helminths and protozoa infecting pregnant women are not affected by these drugs and dosages. To assess the prevalence and diversity of intestinal helminth and protozoan infections, we analyzed stool samples from pregnant women recently enrolled into a birth cohort, along a rural-urban gradient in northern coastal Ecuador from 2019 to 2022.
View Article and Find Full Text PDFTrichuris trichiura, a soil-transmitted helminth (STH), often persists after a single dose of anthelminthic treatment. To overcome limited efficacy against T. trichiura of benzimidazoles (albendazole or mebendazole), the primary drugs used in mass drug administration (MDA) campaigns, the World Health Organization endorses the use of a combination of ivermectin and albendazole as a more effective treatment to be used for preventive chemotherapy.
View Article and Find Full Text PDFPersistent transmission of soil-transmitted helminths despite 16 years of uninterrupted Mebendazole- and ivermectin-based preventive chemotherapy in the Lomie Health District (East Region, Cameroon): The emergency of complementary control strategies.
PLoS Negl Trop Dis
September 2024
Higher Institute of Scientific and Medical Research (ISM), Yaoundé, Cameroon.
Article Synopsis
- The study looked at Soil-Transmitted Helminths (STH) infections in children from Lomie Health District in Cameroon, where they have been deworming schools for many years with a medicine called mebendazole.
- Out of 491 children tested, about 84% were infected with STH, particularly a type called Trichuris trichiura, and many had moderate to heavy infections.
- The study found that poor hand washing and drinking water from rivers increased the chances of getting these infections, suggesting that more needs to be done to improve hygiene and water sources.
Prevalence and intensity of soil-transmitted helminth infections among school-aged children in five districts in Uganda.
PLoS Negl Trop Dis
August 2024
Children Without Worms, The Task Force for Global Health, Decatur, Georgia, United States of America.
Article Synopsis
- Soil-transmitted helminth (STH) infections, particularly affecting Ugandan schoolchildren, have been targeted by biannual deworming efforts since 2003, yet little long-term impact data exists.
- A recent study in November 2023 surveyed 10-14-year-olds in five districts, revealing varying prevalence rates of STH, with the highest at 21.2% in Kamwenge and much lower rates elsewhere.
- Findings indicated that while infections are present, moderate-to-heavy cases are rare across all districts, suggesting effective control of serious STH-related morbidity among schoolchildren.
Acute necrotising pancreatitis from ascariasis in a gravid patient.
BMJ Case Rep
June 2024
Division of Gastroenterology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Metro Manila, Philippines.
Article Synopsis
- A pregnant woman in her 20s presented with 3 days of severe stomach pain and passed a worm, leading to a diagnosis of mild acute pancreatitis.
- Her condition was confirmed by elevated serum lipase levels, while fecal tests showed worm eggs, indicating a parasitic infection.
- After treatment with mebendazole and conservative management of her pancreatic issues, her abdominal pain improved, and she successfully delivered a healthy baby four months later.
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