AI Article Synopsis
- The oral microbiome, composed of various microorganisms, is important in cancer development and progression and is recognized as one of the "Hallmarks of Cancer".
- Factors like maternal transmission and environmental conditions influence the composition and function of the oral microbiota, and disruptions (dysbiosis) can lead to systemic diseases.
- The review highlights the interaction between oral microbiota and their environment, the health effects of this multi-kingdom community, and explores potential mechanisms and therapeutic strategies for targeting oral microbiota in cancer prevention and treatment.
Article Abstract
The polymorphic microbiome has been defined as one of the "Hallmarks of Cancer". Extensive studies have now uncovered the role of oral microbiota in cancer development and progression. Bacteria, fungi, archaea, and viruses in the oral cavity interact dynamically with the oral microenvironment to maintain the oral micro-ecological homeostasis. This complex interaction is influenced by many factors, such as maternal transmission, personal factors and environmental factors. Dysbiosis of oral microbiota can disturbed this host-microbiota interaction, leading to systemic diseases. Numerous studies have shown the potential associations between oral microbiota and a variety of cancers. However, the underlying mechanisms and therapeutic insights are still poorly understood. In this review, we mainly focus on the following aspects: (1) the factors affect oral microbiota composition and function; (2) the interaction between microenvironment and oral microbiota; (3) the role of multi-kingdom oral microbiota in human health; (4) the potential underlying mechanisms and therapeutic benefits of oral microbiota against cancer. Finally, we aim to describe the impact of oral microbiota on cancer progression and provide novel therapeutic insights into cancer prevention and treatment by targeting oral microbiota.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593652 | PMC |
| http://dx.doi.org/10.1007/s43657-023-00124-y | DOI Listing |
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