AI Article Synopsis
- Tendinopathy is a serious condition caused by the degeneration of tendon tissue, which can lead to loss of function and tendon ruptures, and currently has no effective treatments to stop its progression.
- Exosomes are tiny vesicles that carry important substances like proteins and RNAs between cells and are produced by mesenchymal stem cells (MSCs), playing a key role in cell communication and body regulation.
- Recent studies indicate that exosomes derived from MSCs may be promising in promoting tendon healing and could offer new treatment options for tendinopathy.
Article Abstract
Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of mechanical properties and function, and eventual tendon rupture. Unfortunately, there is currently no treatment for tendinopathy that can prevent or delay its progression. Exosomes are small extracellular vesicles that transport bioactive substances produced by cells, such as proteins, lipids, mRNAs, non-coding RNAs, and DNA. They can generate by mesenchymal stem cells (MSCs) throughout the body and play a role in intercellular communication and regulation of homeostasis. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may serve as useful therapeutic candidates for promoting tendon healing. This review focuses on the function and mechanisms of MSCs-exos in tendinopathy treatment and discusses their potential application for treating this condition.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601253 | PMC |
| http://dx.doi.org/10.1186/s13287-023-03431-3 | DOI Listing |
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