Cells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661594 | PMC |
| http://dx.doi.org/10.1016/j.tcb.2023.10.009 | DOI Listing |
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