AI Article Synopsis
- Cardiac involvement in sarcoidosis can affect both patients who show symptoms and those who do not, highlighting the need for deeper understanding of the disease.
- Two autopsy cases are presented where young men experienced sudden death linked to sarcoidosis; one had significant heart changes leading to heart failure, while the other had lung and heart granulomas possibly causing dangerous heart rhythms.
- Detailed post-mortem exams, especially of cardiac conduction pathways, are crucial in determining the cause of sudden deaths related to this condition.
Article Abstract
Cardiac involvement in sarcoidosis has been described in both symptomatic and asymptomatic patients. The aim of this report is to further the understanding of sarcoidosis and its clinical presentation. We report the autopsy and toxicology results of two cases of sudden death in young men. A 37-year-old male had generalized sarcoidosis, in mediastinal glands and intramyocardial sarcoid granulomas in the left ventricle, which had caused a 14mm thickening of the ventricular wall and a secondary dilated myocardiopathy causing sudden death. A 27-year-old male had extensive sarcoidosis of the lungs and mediastinum. Granulomas with a fibrotic background were found in the cardiac wall which could have originated an arrhythmogenic mechanism causing sudden death. Post-mortem study including careful examination of cardiac conduction pathways are vital to ascertain the cause of sudden death.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.patol.2023.04.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!