AI Article Synopsis
- The main goal of a PGT-HLA matching program is to have a healthy baby that can help treat or cure an older sibling who is sick.
- Some people have successfully had healthy babies that match, but there have been many attempts that didn't work.
- The authors studied different ways to improve these programs and shared a success story after a previous failure using their suggested approaches.
Article Abstract
The ultimate goal of a preimplantation genetic testing and human leukocyte antigen (PGT-HLA) matching programme is the birth of a healthy, HLA-compatible child for the treatment or cure of a sick sibling. Several authors have published successful cases of the births of children HLA-matched to siblings affected by different conditions and diseases. However, there are many reports of failed attempts. Couples seeking an HLA-matched sibling for their affected child look for positive outcomes in the shortest possible time. Nevertheless, there is no published consensus or guidelines with recommendations for these cases. Here, the authors aimed to analyse different approaches for these programmes, highlighting the most promising strategies for the families and fertility units. Furthermore, the authors mention a successful case of a PGT-HLA matching programme after a previous failed attempt following the strategies proposed. Which is the most cost-effective and time-efficient approach in a PGT-HLA matching programme?
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| http://dx.doi.org/10.1016/j.rbmo.2023.103400 | DOI Listing |
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