AI Article Synopsis
- Pyrazines are highly reactive compounds that can participate in Diels-Alder reactions with certain activated partners, even at room temperature in a specific kind of reaction.
- The study demonstrated a unique intramolecular cascade reaction leading to the formation of 6- or 7-aza-indazoles.
- Researchers found that different substituents on the reaction precursor affected the distribution of the final products, and NMR studies were used to understand this selectivity better.
Article Abstract
Pyrazines are reactive 4π partners in intermolecular Diels-Alder cycloaddition with exceptionally activated dienophiles or in an intermolecular version at elevated temperatures. Herein, it is shown that an intramolecular cascade could occur even at room temperature, delivering a collection of 6- or 7-aza-indazoles. An interesting substituent effect of the cycloaddition precursor on the product distribution was uncovered, and NMR studies were conducted to gain insights into this unexpected selectivity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.3c03052 | DOI Listing |
Publication Analysis
Top Keywords
divergent synthesis
4
synthesis 7-aza-indazoles
4
7-aza-indazoles intramolecular
4
intramolecular diels-alder
4
diels-alder cascade
4
cascade pyrazines
4
pyrazines pyrazines
4
pyrazines reactive
4
reactive 4π
4
4π partners
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!