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The Evolution of Adhesives Leads to Current Innovations.
Compend Contin Educ Dent
October 2024
Professor of Restorative Dentistry, Chair, Department of Preventive and Restorative Sciences, and Assistant Dean, Digital Innovation and Professional Development, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania.
Adhesive dentistry represents a crucial aspect of daily clinical practice. Occasionally, the introduction of a new material or technique triggers a significant shift in this field. Over the decades, from the largely ineffective systems of the late 1970s and early 1980s to the relatively successful total-etch and self-etch systems of today, the evolution of adhesive systems has been driven by a quest for simplicity, efficiency, and reliability in clinical practice procedures to achieve durable direct and indirect restorations.
View Article and Find Full Text PDFSialic Acid-Targeted Ru(II)/Ir(III)/Re(I) Complexes for Ferroptosis Induction in Triple-Negative Breast Cancer.
Langmuir
December 2024
Department of Chemistry, School of Advanced Sciences (SAS), Vellore Institute of Technology (VIT), Vellore, Tamilnadu 632014, India.
Ferroptosis has been recognized as an iron-based nonapoptotic-regulated cell death process. In the quest of resisting the unyielding vehemence of triple-negative breast cancer (TNBC), herein we have showcased the ferroptosis-inducing heteroleptic [], [], and [] complexes, enabling them to selectively target "sialic acid", an overexpressed cancer cell-surface marker. The open-circuit potential (OCP) measurements in live cancer cells revealed the specific interaction between TNBC and the complexes, whereas control experiments with normal cells did not exhibit such interactions.
View Article and Find Full Text PDFEmployment challenges for persons with visual impairment in Windhoek, Namibia.
Afr J Disabil
October 2024
Department of Psychology and Social Work, Faculty of Health Sciences and Veterinary Medicine, University of Namibia, Windhoek, Namibia.
Background: The greatest challenge for persons with disabilities is that of securing and maintaining employment, because of the limitations associated with being visually impaired.
Objectives: This study aims to explore the employment challenges of securing and maintaining employment faced by persons with visual impairments.
Method: A qualitative research approach with an exploratory research design was employed.
Stereotactic robot-assisted MRI-guided laser interstitial thermal therapy thalamotomy for medically intractable Holmes tremor: a pilot study and literature review.
Neurosurg Focus
November 2024
2Expert Center for Parkinson's Disease, Amiens Picardie University Hospital, Amiens.
Article Synopsis
- Holmes tremor (HT) is a disorder that causes different types of tremors and can severely affect a patient's daily life; traditional medications often fail to provide consistent relief.
- This study examines the effectiveness of a new surgical technique, called MRI-guided laser interstitial thermal therapy (MRIgLITT), focusing on its impact on tremor severity, quality of life (QOL), and adverse effects in patients with persistent HT.
- Results showed notable improvements in tremor severity and QOL, with patients experiencing a 41% reduction in tremors at 3 months and a 29% reduction at 12 months post-surgery, indicating the potential benefits of this treatment approach.
AAV-based TCAP delivery rescues mitochondria dislocation in limb-girdle muscular dystrophy R7.
Brain
October 2024
Department of Neurology, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Article Synopsis
- Limb-girdle muscular dystrophy R7 is a genetic disorder caused by mutations in the TCAP gene, leading to the absence of the protein telethonin and resulting in muscle weakness and mitochondrial dysfunction.
- The research involves a Tcap-deficient mouse model to study the disease's mechanisms and potential treatments, using various experimental techniques like immunofluorescence and proteomics.
- Findings reveal that telethonin is essential for maintaining desmin integrity and proper mitochondrial distribution, and experiments also explore gene therapy using adeno-associated virus to deliver the Tcap gene.
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