This study theorizes and tests an institutional-logics framework to explain why some universities produce more practice-oriented peer-reviewed journal articles than others, using nonprofit studies as an example. Empirically, knowledge production for practice can be increased by (1) graduate degree programs with an emphasis on nonprofit management, (2) research centers on nonprofit studies, and (3) location in disadvantaged communities; however, (4) status as an R1 or R2 research university substantially decreases the production of practical knowledge. Furthermore, (5) research centers can mediate the influence of community needs on knowledge production, so that universities with nonprofit research centers are more responsive to solving community issues. Theoretically, knowledge production follows the institutional logics of both closed and open systems, and institutions such as research centers that can repackage the culture of open systems to make it acceptable to closed systems are essential mediators.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599542 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0293360 | PLOS |
Database (Oxford)
January 2025
Department of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium.
The European Union's ban on animal testing for cosmetic products and their ingredients, combined with the lack of validated animal-free methods, poses challenges in evaluating their potential repeated-dose organ toxicity. To address this, innovative strategies like Next-Generation Risk Assessment (NGRA) are being explored, integrating historical animal data with new mechanistic insights from non-animal New Approach Methodologies (NAMs). This paper introduces the TOXIN knowledge graph (TOXIN KG), a tool designed to retrieve toxicological information on cosmetic ingredients, with a focus on liver-related data.
View Article and Find Full Text PDFCien Saude Colet
January 2025
Universidade Federal do Paraná. R. XV de Novembro 1299, Centro. 80060-000 Curitiba PR Brasil.
J Bacteriol
January 2025
Department of Microbiology and Immunology, Stritch School of Medicine Loyola University Chicago, Chicago, Illinois, USA.
Quorum sensing controls numerous processes ranging from the production of virulence factors to biofilm formation. Biofilms, communities of bacteria that are attached to one another and/or a surface, are common in nature, and when they form, they can produce a quorum of bacteria. One model system to study biofilms is the bacterium , which forms a biofilm that promotes the colonization of its symbiotic host.
View Article and Find Full Text PDF<b>Background and Objective:</b> Peatlands are unique ecosystems rich in microbial diversity, including bacteria with potential antibiotic activity. This study focuses on the isolation and characterization of bacteria from Indonesian peat soil, particularly their potential to produce antibiotics against multidrug-resistant (MDR) pathogens, including Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA). <b>Materials and Methods:</b> Bacterial isolates were rejuvenated on nutrient agar and subjected to antimicrobial activity testing using the Bauer & Kirby diffusion method against MRSA.
View Article and Find Full Text PDFElife
January 2025
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Junior Research Group Synthetic Microbiology, Jena, Germany.
Mycofactocin is a redox cofactor essential for the alcohol metabolism of mycobacteria. While the biosynthesis of mycofactocin is well established, the gene , which encodes an oxidoreductase of the glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes are almost exclusively found in genomes containing mycofactocin biosynthetic genes and are present in 75% of organisms harboring these genes.
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