AI Article Synopsis
- Brainstem injury can develop in up to 2% of children after receiving radiation therapy to the posterior fossa, potentially occurring months or even years post-treatment.
- Young age (under 5 years) and pre-existing health issues like cerebrovascular disease, diabetes, and hypertension increase the risk of this injury.
- Radiation necrosis, which can be serious and fatal, has been linked to a specific genetic mutation (RNF213) that is also associated with moyamoya disease, hinting at a genetic predisposition to this complication.
Article Abstract
Brainstem injury occurs secondary to radiation to the posterior fossa in up to 2% of pediatric patients. It may occur after months to years after treatment. It has been associated with age less than 5 years and with comorbid conditions such as cerebrovascular disease, diabetes mellitus, and hypertension. Radiation necrosis is often symptomatic and can be fatal. A pathogenic variant in RNF213 was found in a patient who suffered fatal radiation necrosis. This mutation has been associated with moyamoya disease and may predispose to radiation necrosis.
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| http://dx.doi.org/10.1002/pbc.30739 | DOI Listing |
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