AI Article Synopsis
- * In the U.S., a specific strain, called the US N. meningitidis urethritis clade (US_NmUC), is responsible for these urethral infections, and researchers have identified similar strains in Japan known as the Japan N. meningitidis urethritis clade (J_NmUC).
- * The study highlights the need for global monitoring of these urethritis-linked meningococci to better understand their spread and characteristics, as they may have a common ancestor that is found worldwide.
Article Abstract
Neisseria meningitidis causes invasive meningococcal diseases and has also been identified as a causative agent of sexually transmitted infections, including urethritis. Unencapsulated sequence type 11 meningococci containing the gonococcal aniA-norB locus and belonging to the United States N. meningitidis urethritis clade (US_NmUC) are causative agents of urethral infections in the United States, predominantly among men who have sex with men. We identified 2 subtypes of unencapsulated sequence type 11 meningococci in Japan that were phylogenetically close to US_NmUC, designated as the Japan N. meningitidis urethritis clade (J_NmUC). The subtypes were characterized by PCR, serologic testing, and whole-genome sequencing. Our study suggests that an ancestor of US_NmUC and J_NmUS urethritis-associated meningococci is disseminated worldwide. Global monitoring of urethritis-associated N. meningitidis isolates should be performed to further characterize microbiologic and epidemiologic characteristics of urethritis clade meningococci.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617353 | PMC |
| http://dx.doi.org/10.3201/eid2911.231082 | DOI Listing |
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Neisseria meningitidis is a common commensal bacterium of the nasopharynx that can cause invasive meningococcal disease (IMD). In comparison, N. gonorrhoeae is always a pathogen usually limited to mucosal sites.
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Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205 USA.
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View Article and Find Full Text PDFArticle Synopsis
- * In the U.S., a specific strain, called the US N. meningitidis urethritis clade (US_NmUC), is responsible for these urethral infections, and researchers have identified similar strains in Japan known as the Japan N. meningitidis urethritis clade (J_NmUC).
- * The study highlights the need for global monitoring of these urethritis-linked meningococci to better understand their spread and characteristics, as they may have a common ancestor that is found worldwide.
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Microb Genom
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Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
) is a bacterial pathogen responsible for invasive meningococcal disease. Though typically colonizing the nasopharynx, multiple outbreaks of meningococcal urethritis were first reported in 2015-2016; outbreaks originally presumed to be caused by (). Genomic analysis revealed that the isolates causing these outbreaks were a distinct clade, and had integrated gonococcal DNA at multiple genomic sites, including the gonococcal denitrification apparatus , a partial gonococcal operon of five genes containing D, and the acetylglutamate kinase gene with the adjacent gonococcal locus .
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