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Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.
J Cell Mol Med
January 2015
INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes, France.
Foetal pig neuroblasts are interesting candidates as a cell source for transplantation, but xenotransplantation in the brain requires the development of adapted immunosuppressive treatments. As systemic administration of high doses of cyclosporine A has side effects and does not protect xenotransplants forever, we focused our work on local control of the host immune responses. We studied the advantage of cotransplanting syngenic mesenchymal stem cells (MSC) with porcine neuroblasts (pNb) in immunocompetent rat striata.
View Article and Find Full Text PDF[[Cyclosporin forever?].
Nephrologie
November 1987
Recherche pré-clinique, Laboratoires Sandoz, Bâle (Suisse).
The author presents a summarized review concerning the use of cyclosporine in the control of graft rejection. He insists on the need to reduce as far as possible the cyclosporine dosage applied. This can be achieved in association with other drugs, such as azathioprine and/or steroids.
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