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Toxicity to intravitreal melphalan in a patient with retinoblastoma. | LitMetric
Description of melphalan's toxicity in retinoblastoma treatment. Clinical case report. We presented a case of unilateral retinoblastoma with vitreous seeding at diagnosis, in which the use of intravitreal melphalan produced many adverse reactions. Vitreous seedings have been one of the most important challenges in retinoblastoma treatment. Intravitreal melphalan has achieved the regression of vitreous seedings in a large percentage of cases. It is a safe treatment; however, it can produce toxicity, even with the standard dose of 20-30 µg, which has been poorly documented. Exhaustive follow-up of patients is recommended for an early diagnosis of possible adverse effects. OS = left eye, RI = magnetic resonance imaging, OCT = optical coherence tomography.
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