AI Article Synopsis
- The intestinal epithelial barrier is crucial in the progression of HIV disease, but its damage in different patient groups is not well understood.
- A study compared intestinal damage and related markers among immunological responders (IRs), immunological non-responders (INRs), and healthy controls.
- It found that both IRs and INRs had persistent intestinal damage, with INRs showing more severe damage, which was linked to higher HIV DNA levels and lower CD4 T cell counts.
Article Abstract
The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological responders (IRs) is largely unknown. In this study, we investigated and compared the levels of intestinal gland damage and related molecules, including the tight junction protein claudin-1, apoptosis marker caspase-3, HIV DNA, CD4 T cell count, and inflammation marker tumor necrosis factor-α (TNF-α) among the IRs (n = 10), INRs (n = 8), and healthy controls (HCs, n = 7). Intestinal damage was not completely restored in both INRs and IRs and was more serious in INRs than that in IRs. Moreover, intestinal damage was positively correlated with HIV DNA levels and negatively correlated with CD4 T cell counts. These results provide insight into understanding the characteristics of intestinal epithelial barrier damage between IRs and INRs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590933 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e20790 | DOI Listing |
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