AI Article Synopsis
- A study on Euphorbia helioscopia L. identified three new ent-atisane diterpenoids and five known compounds through various analytical techniques.
- The structures of the new compounds were determined using methods like NMR and X-ray crystallography, with one compound being notably rare due to a hydroxyl group.
- Bioactivity tests revealed that certain known compounds had significant anti-inflammatory effects by inhibiting NO production in a dose-dependent manner.
Article Abstract
Phytochemical investigation on the anti-inflammatory fraction extracted from the whole plant of Euphorbia helioscopia L. led to the isolation of three new ent-atisane diterpenoids (1-3) and five known analogues (4-8). The structures and absolute configurations of the new compounds were elucidated by comprehensive analysis of the NMR, MS, IR, ECD, and X-ray crystallography. It is worth mentioning that compound 3 belongs to a rare class of ent-atisane diterpenoid featuring a hydroxyl group at C-9. Bioactivity investigation showed that compounds 4, 7, and 8 exhibited significant inhibitory effects on LPS-induced NO production in a dose-dependent manner, which indicates their anti-inflammatory potential.
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| http://dx.doi.org/10.1002/cbdv.202301454 | DOI Listing |
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