A -TsOH/halotrimethylsilane facilitated cycloketonization of -hydroxyl ynones is detailed. This methodology enables the one-step synthesis of polysubstituted 3(2)-furanone products. It is remarkable that the reaction exhibits excellent regio- and chemoselectivity by the addition of very small quantities of -toluenesulfonic acid and water.
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| http://dx.doi.org/10.1039/d3ob01500a | DOI Listing |
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