AI Article Synopsis
- - The retina constantly moves, causing visual signals to be spatially inaccurate, so the brain must adjust these signals for accurate perception and action.
- - The hippocampus plays a crucial role in forming long-term visuospatial memories that are not dependent on the direction of gaze, as shown in studies with rats that struggle to find a hidden escape platform after hippocampal damage.
- - Proprioception in the primary somatosensory cortex is essential for mice to learn the location of a hidden platform, as it helps them develop long-lasting, gaze-independent spatial awareness from visual information; they perform well when the platform is visibly marked.
Article Abstract
Because the retina moves constantly, the retinotopic representation of the visual world is spatially inaccurate and the brain must transform this spatially inaccurate retinal signal to a spatially accurate signal usable for perception and action. One of the salient discoveries of modern neuroscience is the role of the hippocampus in establishing gaze-independent, long-term visuospatial memories. The rat hippocampus has neurons which report the animal's position in space regardless of its angle of gaze. Rats with hippocampal lesions are unable to find the location of an escape platform hidden in a pool of opaque fluid, the Morris Water Maze (MWM) based on the visual aspects of their surrounding environment. Here we show that the representation of proprioception in the dysgranular zone of primary somatosensory cortex is equivalently necessary for mice to learn the location of the hidden platform, presumably because without it they cannot create a long-term gaze-independent visuospatial representation of their environment from the retinal signal. They have no trouble finding the platform when it is marked by a flag, and they have no motor or vestibular deficits.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592928 | PMC |
| http://dx.doi.org/10.1101/2023.10.03.560558 | DOI Listing |
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