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Introduction: Effective antimicrobial stewardship programs require data on antimicrobial consumption (AMC) and utilization (AMU) to guide interventions. However, such data is often scarce in low-resource settings. We describe the consumption and utilization of antibiotics at a large tertiary-level hospital in Uganda.
View Article and Find Full Text PDFMulti-level cognitive state classification of learners using complex brain networks and interpretable machine learning.
Cogn Neurodyn
December 2025
National Engineering Research Center of Educational Big Data, Central China Normal University, Luoyu Road, Wuhan, 430079 Hubei China.
Identifying the cognitive state can help educators understand the evolving thought processes of learners, and it is important in promoting the development of higher-order thinking skills (HOTS). Cognitive neuroscience research identifies cognitive states by designing experimental tasks and recording electroencephalography (EEG) signals during task performance. However, most of the previous studies primarily concentrated on extracting features from individual channels in single-type tasks, ignoring the interconnection across channels.
View Article and Find Full Text PDFImproving obstructive sleep apnea competency of primary care clinicians through online education.
J Am Assoc Nurse Pract
October 2024
School of Nursing and Health Studies, University of Missouri Kansas City, Walton, Kansas.
Background: Obstructive sleep apnea (OSA) is an often overlooked, widespread disease and a public health concern. Evidence-based practice guidelines do not exist to guide primary care clinicians' OSA screening practices. Clinicians must be competent in OSA; however, clinicians lack competency about this disease.
View Article and Find Full Text PDFWATCH: A Workflow to Assess Treatment Effect Heterogeneity in Drug Development for Clinical Trial Sponsors.
Pharm Stat
December 2024
Advanced Methodology and Data Science, Novartis Pharma AG, Basel, Switzerland.
This article proposes a Workflow for Assessing Treatment effeCt Heterogeneity (WATCH) in clinical drug development targeted at clinical trial sponsors. WATCH is designed to address the challenges of investigating treatment effect heterogeneity (TEH) in randomized clinical trials, where sample size and multiplicity limit the reliability of findings. The proposed workflow includes four steps: analysis planning, initial data analysis and analysis dataset creation, TEH exploration, and multidisciplinary assessment.
View Article and Find Full Text PDF[Clinical study on guiding parents to promote oral health of pre-school children through self-made oral science video].
Shanghai Kou Qiang Yi Xue
October 2024
Department of Pediatric Dentistry, Shanghai Xuhui District Dental Center. Shanghai 200032, China. E-mail:
Purpose: To evaluate the clinical effect of self-made oral science video on guiding parents to promote oral health of pre-school children, and to explore a more effective new technology in oral hygiene education.
Methods: One hundred and four 3-6 years old children with early childhood caries from Shanghai Xuhui District Dental Center were randomly recruited and divided into intervention group(n=52) and control group (n=52) during July to September 2022. At recruitment and 1 month after recruitment, the control group received routine oral health education, while the intervention group parents watched self-made oral health video and received routine oral health education.
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