AI Article Synopsis
- The study aimed to explore how persistent pulmonary hypertension (PPHN) and oxygen levels impact the outcomes of newborns with neonatal encephalopathy (NE) receiving therapeutic hypothermia (TH).
- Out of 384 neonates with NE treated with TH, 24% had PPHN, showing they needed higher oxygen levels initially and had lower oxygen levels in the first few days.
- The presence of PPHN was linked to increased intubation rates, hypotension, higher mortality, and a greater risk of brain injuries among the affected neonates.
Article Abstract
Objective: To investigate the effects of persistent pulmonary hypertension (PPHN) and oxygenation on outcome of neonates with neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH).
Study Design: We compared the outcome of neonates with NE treated with TH with or without PPHN.
Results: 384 neonates with NE were treated with TH; 24% had PPHN. The fraction of inspired oxygen was higher in the first 4 days of life (p < 0.001) in neonates with PPHN. They had a significantly lower arterial partial pressure of oxygen in the first 4 days of life (p = 0.005) and higher on days 3-4 of life (p < 0.001). They were more often intubated (p < 0.001) and more often had concomitant hypotension (p < 0.001). They had higher mortality (p = 0.009) and more often developed brain injury (p = 0.02).
Conclusion: PPHN occurred frequently in neonates with NE treated with TH and was associated with a higher incidence of adverse outcome.
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| http://dx.doi.org/10.1038/s41372-023-01805-2 | DOI Listing |
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