AI Article Synopsis
- Antimicrobial resistance (AMR) presents a significant challenge as traditional antibiotics are becoming ineffective against evolving bacterial pathogens.
- Researchers have identified a new macrocycle derivative that, when used alongside vancomycin, effectively eliminates MRSA infections.
- The study includes comprehensive data from in vitro, in vivo, and ADME tests to highlight the potential benefits of this new antibiotic against Salmonella typhimurium strains.
Article Abstract
For a number of years, antimicrobial resistance (AMR) has been a critical issue for humanity. Drug discovery efforts have been very limited and the spread of bacterial pathogens has over-run our traditional arsenal of antibiotics. Bacteria can involve to evade compounds that can halt their rapid growth. The authors have discovered a potent macrocycle derivative that when dosed concomitantly with the standard of care (SOC) antibiotic vancomycin, can clear methicillin resistant Staphylococcus aureus (MRSA) infections. In addition, we have probed the lead compounds in Salmonella typhimurium bacterial strains. In vitro, in vivo, and ADME data have been included to stress the virtues of this new antibiotic.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766536 | PMC |
| http://dx.doi.org/10.1038/s41429-023-00663-6 | DOI Listing |
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