In the course of the past 25 years the indication for pacemaker implantation has changed from AV-block to the sick sinus syndrome in about 40% of patients. In the same period pacemaker technology has developed considerably and today there are, in addition to the ventricular inhibited pacemaker, two-chamber systems (essentially DDD pacemakers) and pacemakers with an increasing pulse rate during physical effort. The new nomenclature, mode of action and hemodynamic implications of the various systems are explained, and recommendations for implantation are given.
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J Endovasc Ther
January 2025
Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirao Preto Medical School, Clinical Hospital of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Introduction: Abdominal aortic aneurysms (AAA) are major causes of morbidity and mortality in the elderly population. Endovascular aneurysm repair (EVAR) is associated with lower complications rates than conventional treatment; however, rigorous follow-up with contrast imaging is required to confirm aneurysmal sac exclusion. The main objective of this study was to quantify and evaluate miRNA expression response to EVAR based on serum dosages at the 6-month follow-up.
View Article and Find Full Text PDFMalawi Med J
January 2025
Access Health Africa.
Aim: An end colostomy is a potentially life-saving surgical intervention, but postoperative ostomy management is challenging in resource-limited settings. Socioeconomic, health system, and surgical capacity barriers may delay colostomy reversal. A surgery camp model for addressing the burden of unreversed colostomies has not previously been undertaken in Malawi.
View Article and Find Full Text PDFLancet Reg Health Am
February 2025
Department of Sexual and Reproductive Health and Research, Including the UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneva, Switzerland.
Problem: In the 1990s, almost 40% of maternal deaths in Uruguay were caused by unsafe abortions.
Approach: A harm reduction model implemented in Uruguay, which addressed the risks associated with unsafe abortion practices by promoting and supporting the self-management of medical abortions by women in their homes, encouraged women's autonomy.
Local Setting: Since 2005, an accelerated decrease in maternal mortality has been recorded in Uruguay, coinciding with the implementation of two major actions: a harm reduction approach with active promotion of self-care through self-management of medical abortions; and in 2012, a change in legislation, which made abortion legal within sexual and reproductive health facilities when requested by women up to 12 weeks of pregnancy or later for specific indications.
Front Oncol
January 2025
Laboratorio de Farmacogenética, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Drug repositioning, the practice of identifying novel applications for existing drugs beyond their originally intended medical indications, stands as a transformative strategy revolutionizing pharmaceutical productivity. In contrast to conventional drug development approaches, this innovative method has proven to be exceptionally effective. This is particularly relevant for cancer therapy, where the demand for groundbreaking treatments continues to grow.
View Article and Find Full Text PDFStudy Design: A retrospective chart review was conducted at a single institution.
Objective: The purpose of this study was to investigate the clinical outcomes of cervical disc arthroplasty (CDA) used for the treatment of symptomatic adjacent segment disease (ASD) developed after anterior cervical discectomy and fusion (ACDF).
Background: A major clinical concern following ACDF is the development of ASD.
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