Circular RNA_0000285: A novel double-edged sword circular RNA in human malignancies.

Circular RNAs (circRNAs) are a class of RNA molecules that are characterized by their covalently closed structure, which is formed through a process of back splicing of the precursor mRNA. Abnormal expression of circRNAs has been shown to indirectly affect their interaction with microRNAs (miRNAs), thereby modulating gene transcription. One such circRNA, circ_0000285, is known to be dysregulated in various cancers and human diseases. This circRNA is derived from the HIPK3 gene on chromosome 11 and acts as a competing endogenous RNA for several miRNAs, including miR-654-3p, miR-197-3p, miR-1278, miR-582-3p, and miR-599. Notably, circ_0000285 has been linked to poor overall survival and several clinicopathological features in multiple human cancers. In this review, we present a comprehensive summary of the oncogenic effect of circ_0000285 in various cancers, drawing on experiment performed on cell lines, animals, and human tissues. Furthermore, we predicted potential miRNAs and RNA-binding proteins that may interact with circ_0000285, thereby providing new insights for further studies.