AI Article Synopsis
- Drug repurposing is being explored as a promising method to expedite drug discovery for cancer treatment.
- The study found that combining Tranylcypromine (TCP) with the NRF2 inhibitor ML385 had synergistic effects, significantly reducing tumor growth compared to using either drug alone.
- Further research is required to fully understand how this combination works and to assess any potential side effects, but the findings indicate a strong potential for effective cancer therapies.
Article Abstract
Drug repurposing has emerged as an attractive strategy for accelerating drug discovery for cancer treatment. In this study, we investigated combining Tranylcypromine (TCP) with a number of well-characterized drugs. Among these combinations, NRF2 inhibitor (ML385) exhibited synergistic effects in combination with TCP. Specifically, our results showed that the combination of TCP and ML385 resulted in a significant reduction in tumor proliferation while neither drug affected cancer cell growth meaningfully on its own. While further studies are needed to understand fully the extent of the synergistic efficacy, the underlying respective mechanisms and the potential side effects of this approach, our study has yielded a promising start for the development of an effective combination cancer therapy.
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| http://dx.doi.org/10.1002/cmdc.202300282 | DOI Listing |
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