The cerebral ventricular size of 15 patients with chronic schizophrenia and 20 age and sex matched controls, has been measured on the basis of the TC scan examination. The schizophrenic patients underwent also a psychometric evaluation by means the WAIS and PM 38 tests. The ventricular size was larger in patients than in normal controls. A significant positive correlation between ventricular measures and the PM 38, some WAIS' sub-tests scores and WAIS Det. % index has been demonstrated and discussed.
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Am J Cardiol
January 2025
Division of Cardiology, Department of medicine, University of Verona, Verona, Italy.
Tricuspid regurgitation (TR) is related to survival and right atrial (RA) size and function may play a role. Our objective is to assess the impact of RA function measured by strain (RAS) on outcome and end organ congestion. We enrolled 134 patients (mean age 73 ± 13 years, 62% women) with any TR grade or etiology and a complete echocardiogram, clinical follow up and renal function assessment.
View Article and Find Full Text PDFASAIO J
December 2024
Cleveland Clinic Florida, Heart, Vascular and Thoracic Institute, Advanced Heart Failure Program, Weston, Florida.
We investigated the association of preimplant left ventricular end-diastolic diameter (LVEDD) with outcomes after HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. Patients from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) registry who underwent HM3 implantation from August 2014 to February 2023 (n = 834) were analyzed according to preoperative LVEDD: less than or equal to 65 (n = 251), 65-80 (n = 441), and greater than or equal to 80 mm (n = 142). The mean age was 54.
View Article and Find Full Text PDFBackground: This study addresses the impact of neighborhood-level socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), on individuals with mild cognitive impairment and dementia. Our primary outcome aimed to explore associations between ADI and hippocampal volume in cognitively impaired individuals from a comprehensive memory center.
Methods: We conducted a retrospective, cross-sectional analysis of patients over 50 from Virginia and North Carolina, with visits between January 1st, 2014, and July 1st, 2022.
Background: The use of biomarkers for early detection of Alzheimer disease (AD) is crucial for developing potential treatments. As neurons die, brain structures, including the hippocampus, shrink and the cerebrospinal fluid spaces ventricles expand. However, due to its small size, hippocampal volumes can be challenging to measure.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is characterized by progressive atrophy of the cerebral cortex and hippocampus, with concomitant increase in ventricular volume. Lomecel-B is a novel cell-based therapeutic approach to AD that targets neuroinflammation, microvascular dysfunction, and has the potential to stimulate endogenous tissue regeneration. We conducted MRI analysis of brain morphology in the CLEAR-MIND study, a 49-patient proof-of-concept study that tested 3 different dosing regimens of Lomecel-B vs placebo in patients with mild AD dementia.
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