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Decoupling Individual Host Response and Immune Cell Engager Cytotoxic Potency.
ACS Nano
January 2025
Aix-Marseille Univ., CNRS, INSERM, LAI, Centuri Living Systems, 13009 Marseille, France.
Immune cell engagers are molecular agents, usually antibody-based constructs, engineered to recruit immune cells against cancer cells and kill them. They are versatile and powerful tools for cancer immunotherapy. Despite the multiplication of engagers tested and accepted in the clinic, how molecular and cellular parameters influence their actions is poorly understood.
View Article and Find Full Text PDFTreatment of Acne With a 1726 nm Laser, Air Cooling, and Real-Time Temperature Monitoring, Software-Assisted Power Adjustment to Achieve a Temperature Endpoint With Selective Sebaceous Gland Photothermolysis.
Lasers Surg Med
January 2025
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Objectives: This work highlights the methods used to develop a multi-pulse 1726 nm laser system combined with bulk air-cooling for selective sebaceous gland (SG) photothermolysis using thermal imaging and software algorithms. This approach enables treating to a desired tissue temperature and depth to provide a safe, effective, reproducible, and durable treatment of acne.
Methods: We designed and built a 1726 nm laser system with a 40 W maximum power output, a highly controlled air-cooling device, and a thermal camera in the handpiece, which permits real-time temperature monitoring of the epidermis.
Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals.
Nat Commun
January 2025
Oxford Molecular Diagnostics Centre, Department of Oncology, University of Oxford, Oxford, UK.
The analysis of circulating tumour DNA (ctDNA) through minimally invasive liquid biopsies is promising for early multi-cancer detection and monitoring minimal residual disease. Most existing methods focus on targeted deep sequencing, but few integrate multiple data modalities. Here, we develop a methodology for ctDNA detection using deep (80x) whole-genome TET-Assisted Pyridine Borane Sequencing (TAPS), a less destructive approach than bisulphite sequencing, which permits the simultaneous analysis of genomic and methylomic data.
View Article and Find Full Text PDFLicensure.
J Am Dent Assoc
January 2025
Board-Certified Orthodontist, Private Practice Limited to Orthodontics, Grayslake, IL; Clinical Assistant Professor, Marquette University, Milwaukee, WI.
Background: Coronavirus disease 2019 resulted in restrictions in didactic and clinical rotations while sites denied entry or limited numbers of nursing student placements to decrease impact staff nurse workload. Pandemic incidences of hospital-acquired infections, central line-associated bloodstream infections (CLABSIs), and catheter-associated urinary tract infections (CAUTIs) increased, underscoring the importance of increasing workforce-ready nurses.
Method: To increase the number of nursing students permitted into the hospital, hospital and school administrators devised the nurse assist program (NAP), which is a collaborative approach developed to address increased staff workloads and personnel shortages and facilitate student return to clinical settings.
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