In this study, we present two cases of , one KPC-33- and one NDM-1-producing, showing resistance to cefiderocol and ceftazidime/avibactam, collected in the intensive care unit of a hospital in Northern Italy from two patients who had recently undergone lung transplantation. Whole-genome sequencing was performed to investigate the molecular features of these strains.
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http://dx.doi.org/10.1089/mdr.2023.0054 | DOI Listing |
Antibiotics (Basel)
December 2024
Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA.
Endophthalmitis is an intraocular microbial infection that can lead to permanent blindness, even with prompt anti-microbial therapy. Multi-drug-resistant organisms are on the rise, potentially limiting the efficacy of current empiric antibiotic therapies of intravitreal ceftazidime and vancomycin. Cefiderocol is a recent FDA- and EMA-approved antibiotic for multi-drug-resistant Gram-negative bacteria.
View Article and Find Full Text PDFClin Microbiol Infect
January 2025
Société Française de Microbiologie, Paris, France.
Front Microbiol
December 2024
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
is a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant Gram-negative bacteria. However, the emergence of -acquired FDC-resistant strains highlights the need for advanced tools to identify resistance-associated genomic mutations and address the challenges of FDC susceptibility testing.
View Article and Find Full Text PDFInfect Dis Ther
December 2024
Department of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical College, No 2 Zheshan West Road, Wuhu, 241000, Anhui, China.
Introduction: Stenotrophomonas maltophilia is an opportunistic pathogen associated with various nosocomial infections and is known for its intrinsic multidrug resistance. This study aims to provide a comprehensive overview of the epidemiology and resistance patterns of S. maltophilia in China from 2014 to 2021.
View Article and Find Full Text PDFCurr Issues Mol Biol
December 2024
Department of Diagnostics and Public Health, Microbiology Section, Verona University, 37134 Verona, Italy.
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