In this study, we present two cases of , one KPC-33- and one NDM-1-producing, showing resistance to cefiderocol and ceftazidime/avibactam, collected in the intensive care unit of a hospital in Northern Italy from two patients who had recently undergone lung transplantation. Whole-genome sequencing was performed to investigate the molecular features of these strains.

Download full-text PDF

Source
http://dx.doi.org/10.1089/mdr.2023.0054DOI Listing

Publication Analysis

Top Keywords

resistance cefiderocol
8
cefiderocol ceftazidime/avibactam
8
concomitant resistance
4
ceftazidime/avibactam carbapenemase-producing
4
carbapenemase-producing isolates
4
isolates lung
4
lung transplant
4
transplant patients
4
patients study
4
study cases
4

Similar Publications

Endophthalmitis is an intraocular microbial infection that can lead to permanent blindness, even with prompt anti-microbial therapy. Multi-drug-resistant organisms are on the rise, potentially limiting the efficacy of current empiric antibiotic therapies of intravitreal ceftazidime and vancomycin. Cefiderocol is a recent FDA- and EMA-approved antibiotic for multi-drug-resistant Gram-negative bacteria.

View Article and Find Full Text PDF

is a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant Gram-negative bacteria. However, the emergence of -acquired FDC-resistant strains highlights the need for advanced tools to identify resistance-associated genomic mutations and address the challenges of FDC susceptibility testing.

View Article and Find Full Text PDF

Introduction: Stenotrophomonas maltophilia is an opportunistic pathogen associated with various nosocomial infections and is known for its intrinsic multidrug resistance. This study aims to provide a comprehensive overview of the epidemiology and resistance patterns of S. maltophilia in China from 2014 to 2021.

View Article and Find Full Text PDF

Updates on the Activity, Efficacy and Emerging Mechanisms of Resistance to Cefiderocol.

Curr Issues Mol Biol

December 2024

Department of Diagnostics and Public Health, Microbiology Section, Verona University, 37134 Verona, Italy.

Article Synopsis
  • Novel antimicrobial drugs, like cefiderocol, have been developed to tackle the rise of antimicrobial resistance, specifically against multidrug-resistant (MDR) Gram-negative bacilli (GNB).
  • Cefiderocol, a unique siderophore cephalosporin, efficiently penetrates bacterial outer membranes, making it effective against various resistance strategies and offering a broad spectrum of action.
  • Despite its effectiveness, recently identified cefiderocol-resistant strains highlight the need for new strategies in clinical practice to maintain its antibacterial efficacy.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!