AI Article Synopsis
- * A total of 52 studies covering 31,285 strains were included, revealing an overall prevalence of 13.4%, with certain study design and sample size factors contributing to variability in findings.
- * The study found that antimicrobial resistance rates to antibiotics like Ampicillin, Cefepime, and Amikacin were generally higher before 2015, indicating a need for continuous monitoring to inform healthcare strategies moving forward.
Article Abstract
To summarize current prevalence and drug resistance rate of () among orthopaedic surgical site infections (SSIs) in China from English and Chinese language sources. Online databases were searched to collect related researches. A -analysis was performed to analyse prevalence and 95 % confidence interval (CI) of among patients with orthopedic surgical site infections. Meta-regression analysis was used to investigate the difference in the prevalence and antimicrobial resistance of among different subgroups. A total of 52 studies were enrolled into our -analysis, with a total of 31,285 strains isolated. The overall prevalence was 13.4 % (95 % CI 11.6-15.5). Study design ( = 8.98) and sample size ( = 10.95) might be potential sources of heterogeneity and there were no significant differences in risk of bias ( = 0.28), study time ( < 0.01), region ( = 2.46) and hospital level ( = 1.42). resistance were reported in 43 of the 52 papers. Antimicrobial resistance of to Ampicillin [87.9 % (95 % CI 83.7-91.1)] before 2015 was higher than that after 2015 [80.3 % (95 % CI 75.0-84.7)] (R = 30.93, = 0.033). While, resistance rate to Cefepime and Amikacin was significantly higher before 2015 ( = 17.25 and 6.54, = 0.043 and 0.048), i.e., 46.4 % (36.3-56.9), 19.9 % (13.8-27.7) and 29.1 % (19.4-41.2), 8.6 % (4.4-16.2) in 2015 and after. It is necessary to carry out long-term monitoring to understand the actual prevalence and antimicrobial resistance of to develop appropriate health care mechanisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587526 | PMC |
| http://dx.doi.org/10.1016/j.pmedr.2023.102452 | DOI Listing |
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