AI Article Synopsis
- The study measured the levels of Trimethoprim (TMP) and Sulfamethoxazole (SMZ) in pleural effusion and plasma in 7 patients during their first, third, and fifth days of treatment.
- The ratio of TMP in pleural fluid to plasma increased steadily, averaging 0.79 by 12 hours, while SMZ peaked at 8 hours on day one (0.53) and rose to 0.71 by day five.
- TMP levels in pleural fluid were found to be lower than typically seen in bronchial secretions, whereas SMZ levels were significantly higher.
Article Abstract
The level of Trimethoprim (TMP) and of Sulfamethoxazole (SMZ) in the fluid of both pleural effusion and plasma was determined in 7 patients on the first day of treatment consisting of two daily doses of 160 mg TMP and 800 mg SMZ. In 4 subjects, the levels were determined again on the third (J3) and fifth day of treatment (J5). Thus with TMP the ratio of pleural/plasma drug levels rose progressively from the first day of treatment to attain by 12 hours a mean value of 0.79 +/- 0.16; subsequently it stayed at about the same level for day 3 (J3) and day 5 (J5). As for SMZ, the ratio of the pleural plasma drug level reached a maximum at 8 hours on the first day of treatment (0.53 +/- 0.12) then rose progressively on day 3 (J3 0.58 +/- 0.06) and on day 5 to 0.71 (+/- 0.08). The levels of TMP in the pleural fluid were below those which are usually described in bronchial secretions. On the other hand those of SMZ are appreciably raised.
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