Objective: To investigate the impact of coronavirus disease 2019 (COVID-19) specified preventive and control measures on the distribution and resistance transition of () in uninfected hospitalized patients during the pandemic.
Methods: This retrospective study retrieved data from 316 isolates in the year pre-COVID-19 (n=131) pandemic and the year under COVID-19 specified preventive and control (post-pandemic year, n=185), compared the general characteristics, laboratory results, and antimicrobial susceptibility tests of between the two groups.
Results: Compared with the pre-pandemic year, the isolation rate of (14.35% vs 22.31%, <0.001) increased, while the rate of drug resistant decreased significantly (29.77% vs 19.45%, <0.001) in the post-pandemic year; Prescription of -Lactams (30.5% vs 50.0%, <0.01) also increased significantly. The resistance rates of isolates to ceftazidime (<0.01), ciprofloxacin (<0.01), and gentamicin (<0.001) increased, whereas the resistance rates to piperacillin/tazobactam (<0.01) and imipenem (<0.05) decreased significantly.
Conclusion: The COVID-19 specified preventive and control measures have influenced the distribution and resistance transition of , further verifications are needed in future research.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588708 | PMC |
| http://dx.doi.org/10.2147/IDR.S423167 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Downregulated CCND3 Is a Key Event Driving Lung Adenocarcinoma Metastasis during Acquired Cisplatin Resistance.
Int J Biol Sci
January 2025
The People's Hospital of Gaozhou, Gaozhou 525200, China.
Cyclin D3 (CCND3), a member of the cyclin D family, is known to promote cell cycle transition. In this study, we found that CCND3 was downregulated in cisplatin-resistant (-diamminedichloroplatinum, DDP) lung adenocarcinoma (LUAD) cells. The loss of CCND3 indeed impeded cell cycle transition.
View Article and Find Full Text PDFTLE1 corepressor promotes gefitinib resistance in lung cancer A549 cells via E‑cadherin silencing.
Biomed Rep
March 2025
Department of Biology, Xavier University of Louisiana, New Orleans, LA 70125, USA.
As a putative lung specific oncogene, the transducin-like enhancer of split 1 (TLE1) corepressor drives an anti-apoptotic and pro-epithelial-mesenchymal transition (EMT) gene transcriptional programs in human lung adenocarcinoma (LUAD) cells, thereby promoting anoikis resistance and tumor aggressiveness. Through its survival- and EMT-promoting gene regulatory programs, TLE1 may impact drug sensitivity and resistance in lung cancer cells. In the present study, a novel function of TLE1 was uncovered as an inhibitor of the antitumor effects of the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) gefitinib in the human LUAD cell line A549, which exhibits moderate sensitivity to EGFR-TKI.
View Article and Find Full Text PDFSingle Precursor-Derived Sub-1 nm MoCo Bimetallic Particles Decorated on Phosphide-Carbon Nitride Framework for Sustainable Hydrogen Generation.
ACS Appl Mater Interfaces
January 2025
Energy and Process Engineering Division, School of Mechanical, Medical and Process Engineering, Science and Engineering Faculty, Queensland University of Technology, 2 George Street, Brisbane City, Queensland 4001, Australia.
The strategic design and fabrication of efficient electrocatalysts are pivotal for advancing the field of electrochemical water splitting (EWS). To enhance EWS performance, integrating non-noble transition metal catalysts through a cooperative double metal incorporation strategy is important and offers a compelling alternative to conventional precious metal-based materials. This study introduces a novel, straightforward, single-step process for fabricating a bimetallic MoCo catalyst integrated within a three-dimensional (3D) nanoporous network of N, P-doped carbon nitride derived from a self-contained precursor.
View Article and Find Full Text PDFElectrochemo-Mechanical Degradation and Failure of Active Particles in High Energy Density Batteries: A Review.
Small
January 2025
Department of Mechanical Engineering, University of Delaware, Newark, DE, 19716, USA.
Failure of the active particles is inherently electrochemo-mechanics dominated. This review comprehensively examines the electrochemo-mechanical degradation and failure mechanisms of active particles in high-energy density lithium-ion batteries. The study delves into the growth of passivating layers, such as the solid electrolyte interphase (SEI), and their impact on battery performance.
View Article and Find Full Text PDFClinical implications of epithelial-to-mesenchymal transition in cancers which potentially spread to peritoneum.
Clin Transl Oncol
January 2025
Unit of Surgical Oncology, Department of Medicine Surgery and Neuroscience, University of Siena, Viale Mario Bracci 16, 53100, Siena, Italy.
Epithelial-to-mesenchymal transition (EMT) is a biological process by which epithelial cells increase their motility and acquire invasive capacity. It represents a crucial driver of cancer metastasis and peritoneal dissemination. EMT plasticity, with cells exhibiting hybrid epithelial/mesenchymal states, and its reverse process, mesenchymal-to-epithelial transition (MET), allows them to adapt to different microenvironments and evade therapeutic intervention.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!