() is an opportunistic arthroconidial yeast-like fungus causing invasive infections in immunocompromised patients, mainly those with hematological malignancies and severe neutropenia. However, infections due to are extremely rare in immunocompetent and non-neutropenic patients. spp. are microscopically characterized by arthroconidia with hyaline-septated hyphae. is known to be intrinsically resistant to echinocandins and highly resistant to fluconazole. It is suggested to use amphotericin B or voriconazole (in monotherapy or in combination) as the gold standard treatment for systemic infections. We report a rare case of peritonitis with fatal outcome in a non-neutropenic patient without underlying malignancies. This case report highlights the value of direct microscopic examination and stained smears in a prompt preliminary diagnosis of invasive fungal infections. We also aim to emphasize the importance of early initiation of appropriate antifungal treatment in patients with systemic infections, thus improving their therapeutic outcome.
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http://dx.doi.org/10.7759/cureus.45568 | DOI Listing |
Clin Infect Dis
January 2025
Infection Control, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Urinary tract infections are prone to overdiagnosis, and reflex urine culture protocols offer a valuable opportunity for diagnostic stewardship in this arena. However, there is no recommended standard testing approach. Cancer patients are often excluded from reflex urine culture protocols, especially if severely immunosuppressed or neutropenic.
View Article and Find Full Text PDFTunis Med
December 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, La Rabta Tertiary Hospital, Intensive Care Medicine Department, 1007, Tunis, Tunisia.
Unlabelled: Introduction Invasive candidiasis (IC) is a widespread infection in intensive care. As culture-based diagnostic techniques take several days before positivity and leaks of sensitivity. (1,3)-β-D-glucan (BDG) was proposed as a mycological criterion for IC diagnosis in selected patients.
View Article and Find Full Text PDFFront Cell Infect Microbiol
December 2024
Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bloodstream infections (BSIs) are a critical concern in pediatric onco-hematological patients undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT), leading to a major impact on morbidity, long-term hospitalization, and mortality. We retrospectively analyzed 202 BSIs in 145 patients, consisting of 128 with hematological malignancies, one with a solid tumor, and 16 with non-malignant hematological diseases. We collected data on patient demographics, clinical characteristics, pathogen distribution, and antimicrobial pathogen susceptibility.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
December 2024
Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing210008, China.
causes a range of diseases in patients with immunodeficiency or underlying pulmonary diseases. -specific immunoglobulin G antibody (Asp-IgG) is produced in response to pathopoiesis. Currently, Asp-IgG is included in the diagnostic criteria for chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA).
View Article and Find Full Text PDFCureus
November 2024
The Michael and Marian Ilitch Department of Surgery, Wayne State University School of Medicine, Detroit, USA.
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