AI Article Synopsis
- * A renal biopsy indicated thrombotic microangiopathy (TMA), characterized by clots in small blood vessels, while cardiac tests revealed significant artery narrowing and heart muscle disease.
- * High levels of amphetamines and methamphetamines were detected in his blood, suggesting a potential link between methamphetamine use and the observed organ dysfunction and kidney damage.
Article Abstract
A 47-year-old man was admitted to our hospital with acute kidney injury, severe hypertension, heart failure, thrombocytopenia, and elevated lactate dehydrogenase. Renal biopsy revealed fibrin thrombi within the glomerular capillaries and moderate fibrotic intimal thickening in the interlobular arteries. The histological diagnosis was thrombotic microangiopathy (TMA). Regarding cardiac involvement, we found marked stenosis in the left anterior descending artery on coronary angiography and cardiomyopathy on myocardial biopsy. Blood concentrations of amphetamine and methamphetamine were high (14.1 ng/mL and 333 ng/mL, respectively). It is important to consider methamphetamine as a cause of renal TMA and multi-organ dysfunction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189718 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.2143-23 | DOI Listing |
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