Mercury (Hg) is a highly toxic metal and can cause severe damage to many organisms under natural conditions. As an effective free radical scavenger and antioxidant, Melatonin (MT) has played important protective roles in alleviating oxidative damage caused by environmental cues including heavy metal stress in plants. However, the detailed mechanisms of melatonin in alleviating Hg toxicity still remain unclear in plants. Our results showed that the application of melatonin greatly reduced the concentrations of total and intracellular Hg in Taxiphyllum taxirameum. Meanwhile, melatonin significantly improved the antioxidant capacity and thus alleviated oxidative damage to the chloroplasts of T. taxirameum under Hg stress. Metabolic pathway analysis further revealed that melatonin-treated plants exhibited higher levels of 48 metabolites, including sugars, amino acids, and lipids, than non-melatonin-treated plants under Hg stress. Additionally, we further found that melatonin addition greatly improved the concentrations of four organic acids and three amino acids (Orn, Cit and Arg) related to the urea cycle, and thereby changed the levels of putrescine (Put) and spermidine (Spd) in T. taxirameum exposed to Hg stress. Further experiments showed that the high concentration of Put dramatically caused oxidative damage under Hg stress, while Spd effectively alleviated Hg toxicity in T. taxirameum. Taken together, this study provides new insight into the underlying mechanisms of melatonin in alleviating heavy metal toxicity in plants.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.scitotenv.2023.167958 | DOI Listing |
Biol Trace Elem Res
December 2024
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Previous studies have proved trace mineral disorders to be related to changes in oxidative stress, inflammatory state, and immune response in asthmatics. However, there is a scarcity of studies that examine the correlation between copper intake with mortality in asthmatic people. The aim of this research was to investigate the effect of copper intake on the asthmatic population's mortality.
View Article and Find Full Text PDFCancer Cell Int
December 2024
Department of Applied Chemistry, Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Puli, Taiwan.
Introduction: Chronic alcohol consumption and tobacco usage are major risk factors for esophageal squamous cell carcinoma (ESCC). Excessive tobacco and alcohol consumption lead to oxidative stress and the generation of reactive carbonyl species (RCS) which induce DNA damage and cell apoptosis. This phenomenon contributes to cell damage and carcinogenesis in various organs including ESCC.
View Article and Find Full Text PDFExp Eye Res
December 2024
Department of Biochemistry, Post-Graduate Program in Biochemistry and Post-Graduate Program in Pharmacology, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil. Electronic address:
High intraocular pressure (HIOP) and high glucose levels are associated with oxidative stress. Although physical exercise protects against oxidative damage, its specific impact on eye health remains unclear. Thus, this study aimed to assess the impact of physical exercise on the oxidative status of whole eyes in male Swiss mice subjected to HIOP model and cafeteria diet (CD).
View Article and Find Full Text PDFFood Chem
December 2024
State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
Diabetic nephropathy (DN) is one of the most serious and prevalent complications associated with diabetes. Consequently, antidiabetic drugs or foods potentially protecting the kidneys are of significant therapeutic value. Sulforaphene (SFE) is a natural isothiocyanate derived from radish seeds, known for its anti-inflammatory and antioxidant properties.
View Article and Find Full Text PDFAnim Reprod Sci
December 2024
Key Laboratory for Animal Science of National Ethnic Affairs Commission, Southwest Minzu University, Chengdu 610041, China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation of Ministry of Education, Southwest Minzu University, Chengdu 610041, China. Electronic address:
Low-temperature preservation of yak semen during transportation and conservation is crucial to accelerate yak breeding. The effects of low-temperature cooling on yak semen quality, however, are poorly understood. This study aimed to determine the dose-dependent effect of mitochondria-targeted antioxidant "MitoQ" on the motility, oxidative status, and mitochondrial function of yak semen during low-temperature preservation.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!