AI Article Synopsis
- * In a sample of 128 MEC cases, researchers found that p16 expression was present in 76% of cases, and lymphoid stroma was observed in 49%, with both factors linked to better clinical outcomes and survival rates.
- * The study concluded that p16 expression and lymphoid stroma presence could serve as valuable prognostic tools to improve the treatment and prediction of outcomes for MEC patients.
Article Abstract
Background: Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. This study was designed to identify valuable prognosticator in MEC.
Methods: Histopathologic analysis, immunohistochemistry, and in situ hybridization were performed on 128 carcinomas diagnosed as MEC of the head and neck.
Results: Expression of p16 was found in 96 cases (76%) of MEC. Lymphoid stroma was identified in 63 cases (49%). There was a significant correlation between loss of p16 expression and absence of lymphoid stroma. Expression of p16 was significantly associated with better clinicopathologic features. Lymphoid stroma was significantly associated with lower histologic grade. Overall survival (OS) was significantly longer in cases expressing p16 (P = 0.00096) and lymphoid stroma cases (P = 0.0023). Multivariate analysis revealed loss of p16 expression as negative prognosticators for OS.
Conclusion: Our data showed p16 expression and the presence of lymphoid stroma were significantly associated with good clinical outcomes. Testing for these factors could lead to better prognostication and treatment of patients with MEC.
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| http://dx.doi.org/10.1016/j.prp.2023.154874 | DOI Listing |
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