Study Objective: End-tidal carbon dioxide (etCO) is used to guide ventilation after achieving return of spontaneous circulation (ROSC) in certain out-of-hospital systems, despite an unknown difference between arterial and end-tidal CO (partial pressure of carbon dioxide [paCO]-etCO difference) levels in this population. The primary aim of this study was to evaluate and quantify the paCO-etCO difference in out-of-hospital patients with ROSC after nontraumatic cardiac arrest.
Methods: This retrospective single-center study included patients aged 18 years and older with sustained ROSC after nontraumatic out-of-hospital cardiac arrest. In patients with an existing out-of-hospital arterial blood gas analysis within 30 minutes after achieving ROSC, matching etCO values were evaluated. Linear regression and Bland-Altman plot analysis were performed to ascertain the primary endpoint of interest.
Results: We included data of 60 patients in the final analysis. The mean paCO-etCO difference was 32 (±18) mmHg. Only a moderate correlation (R=0.453) between paCO and etCO was found. Bland-Altman analysis showed a bias of 32 mmHg (95% confidence interval [CI], 27 to 36) [the upper limit of agreement of 67 mmHg (95% CI, 59 to 74) and the lower limit of agreement of -3 mmHg (95% CI, -11 to 5)].
Conclusion: The paCO-etCO difference in patients with ROSC after out-of-hospital cardiac arrest is far from physiologic ranges, and the between-patient variability is high. Therefore, etCO-guided adaption of ventilation might not provide adequate accuracy in this setting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.annemergmed.2023.03.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantitative analysis of amino acid excretion by Methanothermobacter marburgensis under N-fixing conditions.
Sci Rep
January 2025
Archaea Physiology & Biotechnology Group, Department of Functional and Evolutionary Ecology, University of Vienna, Wien, Austria.
Methanogenic archaea (methanogens) possess fascinating metabolic characteristics, such as the ability to fix molecular nitrogen (N). Methanogens are of biotechnological importance due to the ability to produce methane (CH) from molecular hydrogen (H) and carbon dioxide (CO) and to excrete proteinogenic amino acids. This study focuses on analyzing the link between biological methanogenesis and amino acid excretion under N-fixing conditions.
View Article and Find Full Text PDFImpact of gas composition, pressure, and temperature on interfacial Tension dynamics in CO₂-Enhanced oil recovery.
Sci Rep
January 2025
King Fahd University of Petroleum & Minerals, Dhahran, 31261, Saudi Arabia.
Climate change policies are driving the oil and gas industry to explore CO injection for carbon dioxide storage in reservoirs. In the United States, a substantial portion of oil production relies on CO-enhanced-oil-recovery (CO-EOR), demonstrating a growing interest in using CO to address various production challenges like condensate mitigation, pressure maintenance, and enhancing productivity in tight reservoirs. CO injection introduces gases like natural gas and N, either pre-existing or as impurities in the injected CO gas.
View Article and Find Full Text PDFTransient pulsed discharge preparation of graphene aerogel supports asymmetric Cu cluster catalysts promote CO electroreduction.
Nat Commun
January 2025
School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, 100081, China.
Designing asymmetrical structures is an effective strategy to optimize metallic catalysts for electrochemical carbon dioxide reduction reactions. Herein, we demonstrate a transient pulsed discharge method for instantaneously constructing graphene-aerogel supports asymmetric copper nanocluster catalysts. This process induces the convergence of copper atoms decomposed by copper chloride onto graphene originating from the intense current pulse and high temperature.
View Article and Find Full Text PDFEnhanced capacity in cellulose aerogel for carbon dioxide capture through modified by metal-organic framework.
Int J Biol Macromol
January 2025
College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, PR China. Electronic address:
Microporous metal-organic frameworks (MOF) exhibit excellent carbon dioxide (CO) adsorption performance and selectivity for CO/N separation. However, the challenges associate with the recycling and reuse of MOF powders hinder their practical applications. To address these limitations, a flexible and stable MOF-based composite material was designed by immobilizing UiO-66(Zr)-(OH) onto cellulose nanofibers (CNFs) aerogels (MOF-CNFs), which featured high porosity.
View Article and Find Full Text PDFConformational dynamics of a multienzyme complex in anaerobic carbon fixation.
Science
January 2025
Redox and Metalloprotein Research Group, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
In the ancient microbial Wood-Ljungdahl pathway, carbon dioxide (CO) is fixed in a multistep process that ends with acetyl-coenzyme A (acetyl-CoA) synthesis at the bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase complex (CODH/ACS). In this work, we present structural snapshots of the CODH/ACS from the gas-converting acetogen , characterizing the molecular choreography of the overall reaction, including electron transfer to the CODH for CO reduction, methyl transfer from the corrinoid iron-sulfur protein (CoFeSP) partner to the ACS active site, and acetyl-CoA production. Unlike CODH, the multidomain ACS undergoes large conformational changes to form an internal connection to the CODH active site, accommodate the CoFeSP for methyl transfer, and protect the reaction intermediates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!