Crosslinked carboxymethyl cellulose colloidal solution for cotton thread coating in wound dressing: A rheological study.

Cotton thread therapeutic properties as a wound dressing can be enhanced by utilising carboxymethyl cellulose-nanoparticles (CMC/NPs) colloidal solution as a coating solution. Nanoparticles such as graphene oxide (GO), graphene quantum dots (GQD), and silver nanoparticles (AgNP) stability in CMC was investigated through the rheological analysis and UV-Vis spectroscopy of the colloidal solutions. Citric acid (CA) acted as a crosslinker and was utilised to crosslink the colloidal solution with cotton thread. These CMC/NPs coated threads were subjected to mechanical properties and antibacterial activity analysis. Results obtained indicate less nanoparticle agglomeration and were stable in the CMC-based nanofluid. CMC/NPs rheological study suggested that colloidal solutions exhibited shear thinning behaviour and behaved as non-Newtonian fluids with n < 1. Crosslinked CMC/NPs appeared in a gel-like state as the viscoelasticity of the solution increased. Among the colloidal solutions, CMC/AgNP showed the highest enhancement with a significant difference at p < 0.05 in terms of mechanical and antibacterial properties. Consequently, the rheological properties and stability of CMC/NPs might influence the coating solution's appearance and refine the cotton thread's microstructure for a functional wound dressing to be further utilised as a coating solution for antibacterial cotton thread wound dressing material.