Macrophages, MIFs, and MSCs: Defining an MOA in murine experimental asthma.

Mol Ther

University of Wisconsin School of Medicine and Public Health, University of Wisconsin in Madison, Madison, WI, USA. Electronic address:

Published: November 2023

The mechanistically defined attributes of primed MSCs as here described not only provide a novel use case of MIF activated MSCs that can address the potency shortcomings of generic culture-adapted MSCs for acute lung injury but also provide some intriguing "Rosetta Stone" insights on plausible in vivo physiology of MSCs with host innate effectors such as macrophages in response to inflammation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638068PMC
http://dx.doi.org/10.1016/j.ymthe.2023.10.010DOI Listing

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