AI Article Synopsis

  • - Allergic diseases, including asthma, are on the rise globally, with allergies contributing significantly to asthma development in about 60% of adults and 80% of children.
  • - Common allergens linked to asthma include pollens, mites, fungi, and animal dander, with fungi being a major cause of respiratory issues that can be severe and hard to avoid.
  • - There's a lack of detailed knowledge about fungal allergens compared to other allergens, which is important for accurate diagnosis, predicting asthma flare-ups, and creating personalized treatment plans as environmental conditions change.

Article Abstract

Allergic diseases are a major health problem due to their increasing incidence and high prevalence worldwide. Asthma has several aetiologies, and allergy plays an important role in its development in approximately 60% of adults and 80% of children and adolescents. Although the link between aeroallergen sensitization and asthma exacerbations has been long recognized, the investigations of the triggering allergens may be superficial in many asthma cases. The main allergenic sources related to asthma, and other allergic diseases, are pollens, mites, fungi, and animal epithelia. Fungi are considered the third most frequent cause of respiratory pathologies. Asthma caused by several fungi species may have a bad prognosis in some cases due to its severity and difficulty in avoidance methods. Despite the recognised relevance of fungi in respiratory allergies, the knowledge about fungal allergens seems to be scarce, with few descriptions of new allergens, compared to other allergenic sources. The study of major, minor, and cross-reactive fungal allergens, and their relevance in the allergic disease, might be crucial, not only to accurately diagnose these allergies, but also to predict exacerbations and responses to therapies, as well as for the development of personalized treatment plans in a fast-changing climate scenario.

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Source
http://dx.doi.org/10.1016/j.molimm.2023.09.017DOI Listing

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