Objectives: The current study examined whether informal caregivers performed worse, better, or similar to non-caregivers on cognitive tests of executive functioning and episodic memory over 10 years. Data were from waves 2 (2003-04) and 3 (2013-14) of the Midlife in the United States (MIDUS) study ( = 2086). Multiple linear regression models examined whether caregiving at both waves 2 and 3 predicted better cognitive functioning at wave 3, than caregiving at only one time point or no caregiving (reference) while controlling for baseline covariates (i.e., sociodemographic, health, and functional status).
Results: After controlling for covariates, caregiving at both waves was independently associated with better performance in episodic memory ( = .24, = .10, = .013) but not executive function ( = -.06, = .05, = .246). The findings partially supported both healthy caregiver and stress process models, indicating caregiving may be associated with better episodic memory but not executive functioning over time among the middle-aged and older adults.
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http://dx.doi.org/10.1177/08982643231209482 | DOI Listing |
Nature
January 2025
Department of Brain and Cognitive Sciences and McGovern Institute, MIT, Cambridge, MA, USA.
Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for navigation, and the storage of sequential episodic memories. Although there have been advances in modelling spatial representations in the hippocampus, we lack good models of its role in episodic memory. Here we present a neocortical-entorhinal-hippocampal network model that implements a high-capacity general associative memory, spatial memory and episodic memory.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA.
Childhood cognitively stimulating activities have been associated with higher cognitive function in late life. Whether activities in early or late childhood are more salient, and whether activities are associated with specific cognitive domains is unknown. Participants retrospectively reported cognitively stimulating activities at ages 6, 12, and 18 years.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCL, London, WC1N 3BG, UK.
Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on memory function are unclear. Our study investigates neural mechanisms of memory recovery and network plasticity over nearly a decade post-surgery.
View Article and Find Full Text PDFLupus
January 2025
Internal Medicine Department, Habib Thameur Hospital, Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.
Objective: Cognitive impairment (CI) in systemic lupus erythematosus (SLE) is quite common and is an important prognostic factor due to its severity. The aim of our study was to determine the proportion and type of CI in SLE and to identify associated risk factors.
Methods: We performed a cross-sectional study (January - March 2022).
Psychiatry Res
January 2025
Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands.
Accumulating evidence supports the efficacy of (es)ketamine in the treatment of major depressive disorder (MDD), particularly treatment-resistant depression (TRD). Yet around 50% of the individuals with TRD do not respond to (es)ketamine. Elucidating predictors of response and remission could improve treatment outcomes at the individual level by defining subpopulations that are most likely to benefit from (es)ketamine.
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