AI Article Synopsis

  • - The study aimed to explore the diagnosis and treatment of hemiplegic shoulder pain (HSP) by analyzing changes in pain-related substances in the blood and included 34 patients with shoulder pain and 21 control subjects.
  • - Results showed that individuals with HSP had significantly lower pain-free shoulder mobility and higher signs of anxiety and depression compared to the control group; spasticity in elbow muscles was also more prevalent in the HSP group.
  • - Key findings indicated that certain pain mediators (CGRP, IL-10, IL-2) were elevated in HSP patients, while others (NGF, TNF-α, IL-6, etc.) were decreased, suggesting that HSP might be

Article Abstract

Objective: To provide a new insight into the diagnosis and treatment of hemiplegic shoulder pain (HSP) by investigating changes in serum pain mediators.

Design: Cross-sectional study.

Subjects/patients: Shoulder pain group (n = 34) and control group (n = 21).

Methods: Pain-free shoulder mobility, anxiety status, depression status, and shoulder pain were measured by passive range of motion (PROM), self-rating anxiety scale, self-rating depression scale (SDS), and visual analog scale, respectively. The enzyme-linked immunosorbent assay was used to test the serum pain mediators, including interleukin (IL)-1β, IL-2, IL-6, IL-10, nerve growth factor (NGF), tumor necrosis factor-α (TNF-α), substance P (SP), calcitonin gene-related peptide (CGRP), bradykinin (BK), 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2), and lysophosphatidic acid (LPA).

Results: Shoulder pain group pain-free PROM significantly lower than control (p < .01), and SDS index score of shoulder pain group was significantly higher than control (p < .05). The rate of spasticity in the flexor elbow muscles is higher in shoulder pain group (p < .01). CGRP, IL-10, and IL-2 were significantly upregulated in shoulder pain group compared with control (p < .01), whereas NGF, TNF-α, IL-6, 5-HT, PGE2, SP, LPA, BK, and IL-1β were significantly decreased (p < .01).

Conclusion: Patients with HSP have a higher risk of joint mobility disorders and depression; spasticity may be an important factor in the development of shoulder pain; CGRP is thought to be the major pain mediator in HSP, and HSP may not be inflammatory.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726773PMC
http://dx.doi.org/10.1002/brb3.3289DOI Listing

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