AI Article Synopsis

  • Orthopoxviruses, including the monkeypox virus (MPXV), have shown unpredictable patterns of illness and spread, first noted in the late 1950s among primates and later causing human cases in Africa since the 1970s.
  • In May 2022, a new MPXV outbreak emerged notably among gay, bisexual, and other men who have sex with men, marking a shift in transmission dynamics.
  • The article discusses prior knowledge of mpox, insights gained during the 2022 outbreak, and the ongoing research needed to enhance global health measures against this virus.

Article Abstract

Orthopoxviruses have repeatedly confounded expectations in terms of the clinical illness they cause and their patterns of spread. Monkeypox virus (MPXV), originally characterized in the late 1950s during outbreaks among captive primates, has been recognized since the 1970s to cause human disease (mpox) in West and Central Africa, where interhuman transmission has largely been associated with nonsexual, close physical contact. In May 2022, a focus of MPXV transmission was detected, spreading among international networks of gay, bisexual, and other men who have sex with men. The outbreak grew in both size and geographic scope, testing the strength of preparedness tools and public health science alike. In this article we consider what was known about mpox before the 2022 outbreak, what we learned about mpox during the outbreak, and what continued research is needed to ensure that the global public health community can detect, and halt further spread of this disease threat.

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Source
http://dx.doi.org/10.1093/infdis/jiad465DOI Listing

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