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Family Care-Giving for Pediatric Hospitalists: Invisible, Unspeakable, Unbearable Lightness.
Hosp Pediatr
January 2025
Department of Medical Humanities and Ethics, Division of Narrative Medicine, Columbia Vagelos College of Physicians and Surgeons, New York, New York.
Measurable Residual Disease in Mantle Cell Lymphoma: The Unbearable Lightness of Being Undetectable.
Curr Oncol Rep
December 2024
Department of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
Purpose Of Review: This paper evaluates the benefits and limitations of detecting measurable residual disease (MRD) in mantle cell lymphoma (MCL) and assesses its prognostic value. It also aims to highlight the importance of detecting low MRD levels post-treatment and their application in clinical practice.
Recent Findings: Recent studies show that MRD levels predict relapse and survival outcomes in hematologic neoplasms, including MCL.
"The unbearable lightness" of the primary end point in clinical trials.
Mol Cell Biochem
August 2024
Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston, 6770 Bertner Street, Suite C900A, Houston, TX, 77030, USA.
In this Perspective, I discuss the limitations of a soft primary endpoint that is used in some of the recent randomized phase II/III clinical trials. Unfortunately, many clinicians and investigators do not interpret the data critically to recognize the limitations of such findings. I advise against over-interpreting the effects of an intervention on a soft primary endpoint.
View Article and Find Full Text PDFSuccessful treatment by a chlorin e6 derivative mediated photodynamic therapy combined holmium laser for cervical and vaginal giant condyloma acuminata and low-grade intraepithelial neoplasia:A case report.
Photodiagnosis Photodyn Ther
April 2024
Shanghai Skin Disease Hospital, School of Medicine, Institute of Photomedicine, Tongji University, 1278 Baode Road, Shanghai 200443, China. Electronic address:
Photodynamic therapy (PDT) is proved effective for treating low-grade squamous intraepithelial lesions (LSIL) and condylomata acuminata (CA). 5-Aminolevulinicacid (5-ALA) is the most common applied photosensitizer, but high rate of unbearable pain and relative long incubation time were reported. Here, we report a 27-year-old woman suffering from cervical and vaginal giant CA with LSIL involving the whole right vaginal fornix, cervical surface, and vaginal wall.
View Article and Find Full Text PDFThe unbearable lightness of being opinionated.
J Physiol
December 2023
Department of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, Australia.
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