In this paper, we consider the current and potential role of the latest generation of Large Language Models (LLMs) in medical informatics, particularly within the realms of clinical and anatomic pathology. We aim to provide a thorough understanding of the considerations that arise when employing LLMs in healthcare settings, such as determining appropriate use cases and evaluating the advantages and limitations of these models. Furthermore, this paper will consider the infrastructural and organizational requirements necessary for the successful implementation and utilization of LLMs in healthcare environments. We will discuss the importance of addressing education, security, bias, and privacy concerns associated with LLMs in clinical informatics, as well as the need for a robust framework to overcome regulatory, compliance, and legal challenges.
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http://dx.doi.org/10.1016/j.jpi.2023.100338 | DOI Listing |
NPJ Digit Med
January 2025
Observational Health Data Science and Informatics, New York, NY, USA.
Using administrative claims and electronic health records for observational studies is common but challenging due to data limitations. Researchers rely on phenotype algorithms, requiring labor-intensive chart reviews for validation. This study investigates whether case adjudication using the previously introduced Knowledge-Enhanced Electronic Profile Review (KEEPER) system with large language models (LLMs) is feasible and could serve as a viable alternative to manual chart review.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Engineering, iHealth Labs, Sunnyvale, CA, 94085, United States.
Large language models (LLMs) are fundamentally transforming human-facing applications in the health and well-being domains: boosting patient engagement, accelerating clinical decision-making, and facilitating medical education. Although state-of-the-art LLMs have shown superior performance in several conversational applications, evaluations within nutrition and diet applications are still insufficient. In this paper, we propose to employ the Registered Dietitian (RD) exam to conduct a standard and comprehensive evaluation of state-of-the-art LLMs, GPT-4o, Claude 3.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Centre for Medical Education, University of Dundee, Dundee, Scotland.
Background: Like other countries developing standardized general practice training, China faces the challenge of training vast numbers of new general practice faculty. However, little is known about these clinician-teachers' motivations and perceived needs for faculty development. This review intended to explore available published data on Chinese general practice faculty development needs and motivation for ongoing professional development.
View Article and Find Full Text PDFNeuroimage
January 2025
Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan. Electronic address:
In recent decades, converging evidence has reached a consensus that human speech production is carried out by large-scale hierarchical network comprising both language-selective and domain-general systems. However, it remains unclear how these systems interact during speech production and the specific contributions of their component regions. By utilizing a series of meta-analytic approaches based on various language tasks, we dissociated four major systems in this study: domain-general, high-level language, motor-perception, and speech-control systems in this study.
View Article and Find Full Text PDFComput Methods Programs Biomed
January 2025
Laberit, Avda. de Catalunya, 9, València, 46020, Spain.
Background And Objective: Despite significant investments in the normalization and the standardization of Electronic Health Records (EHRs), free text is still the rule rather than the exception in clinical notes. The use of free text has implications in data reuse methods used for supporting clinical research since the query mechanisms used in cohort definition and patient matching are mainly based on structured data and clinical terminologies. This study aims to develop a method for the secondary use of clinical text by: (a) using Natural Language Processing (NLP) for tagging clinical notes with biomedical terminology; and (b) designing an ontology that maps and classifies all the identified tags to various terminologies and allows for running phenotyping queries.
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