Study on extraction technology and antioxidant activity of total alkaloids from based on orthogonal design and BP neural network.

Heliyon

National-Local Joint Engineering Research Center on Gemplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, 650201, China.

Published: October 2023

AI Article Synopsis

  • The study focused on extracting total alkaloids to evaluate their antioxidant properties using a combination of experiments and advanced testing methods.
  • Optimized extraction conditions were determined to be 0.50% HCl concentration, 85°C temperature, and a 1:64.5 material-liquid ratio, yielding an extraction rate of 0.2785 ± 0.0003 mg/mL.
  • The extracted alkaloids demonstrated positive antioxidant activity, indicating the efficiency of the extraction process and its potential application in developing natural medicinal resources for pharmaceuticals and food.

Article Abstract

In this study, total alkaloids from were extracted and tested for their antioxidant properties. To optimize extraction methods, a single factor experiment was conducted to determine the total alkaloid concentrations of using the L (3) orthogonal design test method and the BP neural network (BPNN), resulting in the optimum extraction conditions for total alkaloids. The optimal conditions for alkaloids extraction with acid water are: HCl concentration is 0.50 %, extraction temperature is 85 °C, material-liquid ratio is 1:64.5, and extraction rate of alkaloids is 0.2785 ± 0.0003 mg/mL. The alkaloid from exhibited antioxidant activity in a quantity-effect relationship with activity. These findings showed that the procedure to be reasonable, the alkaloid extraction efficiency to be high, and the method could be used to extract the alkaloids of , improving the development of natural and healthy medicinal resources for the pharmaceutical and food industries.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582500PMC
http://dx.doi.org/10.1016/j.heliyon.2023.e20680DOI Listing

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