AI Article Synopsis
- BCL2 helps maintain the health of mitochondria, which in turn stops innate immune responses and prevents cell death.
- Recent findings show that BCL2 also reduces dendritic cells' ability to trigger adaptive immune responses.
- This suggests that BCL2 plays a broader role in immune suppression, acting as a mitochondrial checkpoint that affects various immune functions.
Article Abstract
BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583618 | PMC |
| http://dx.doi.org/10.1080/2162402X.2023.2271693 | DOI Listing |
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