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http://dx.doi.org/10.3389/fphar.2023.1274139 | DOI Listing |
Biogerontology
January 2025
Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Alzheimer's disease (AD) and osteoporosis (OP) pose distinct but interconnected health challenges, both significantly impacting the aging population. AD, a neurodegenerative disorder characterized by memory impairment and cognitive decline, is primarily associated with the accumulation of abnormally folded amyloid beta (Aβ) peptides and neurofibrillary tangles in the brain. OP, a skeletal disorder marked by low bone mineral density, involves dysregulation of bone remodeling and is associated with an increased risk of fractures.
View Article and Find Full Text PDFFront Microbiol
January 2025
Department of Chemistry, University of Ioannina, Ioannina, Greece.
Future Healthc J
December 2024
Associate editor of the Future Healthcare Journal, Royle College of Physicians, London, United Kingdom.
Front Pharmacol
January 2025
Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
Introduction: The field of pharmacogenetics (PGx) is experiencing significant growth, with increasing evidence to support its application in psychiatric care, suggesting its potential to personalize treatment plans, optimize medication efficacy, and reduce adverse drug reactions. However, the perceived utility and practicability of PGx for psychiatric treatment in youth remains underexplored. This study investigated perceived barriers and attitudes in Australian young adults towards the implementation of PGx testing to guide antidepressant treatment in primary care.
View Article and Find Full Text PDFFront Cell Dev Biol
January 2025
Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Pisa, Italy.
Introduction: Recent research revealed that Tau plays critical roles in various neuronal functions. We previously demonstrated that destabilization and nuclear delocalization of Tau alter the expression of glutamatergic genes, mediating early neuronal damage.
Methods: In this study, we discovered that changes in Tau availability are linked to global alterations in gene expression that affect multiple neuronal pathways.
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